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Table 3 Model calibration results

From: Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

Parameter name

Range in parameter space

Estimated value

pr bD4

[0–1]

0.841699

pr upD4

[0–1]

0.484118

pr tpRbDephos

[0–1]

1

pr uE2F

[0–1]

0.612768

pr bE2F

[0–2]

1.88407

pr bE2A2A1

[0–1]

0.130145

pr upE2A2A1

[0–1]

0.428204

ModifierTime

120–780 min

675.993 min

K sCyclinD

100–2000 ((molecules/cell)/min)

1761.08 ((molecules/cell)/min)

Cyclin D

Initial Levels

10000–20000 (molecules/cell)

19264 (molecules/cell)