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Table 3 Model calibration results

From: Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

Parameter name Range in parameter space Estimated value
pr bD4 [0–1] 0.841699
pr upD4 [0–1] 0.484118
pr tpRbDephos [0–1] 1
pr uE2F [0–1] 0.612768
pr bE2F [0–2] 1.88407
pr bE2A2A1 [0–1] 0.130145
pr upE2A2A1 [0–1] 0.428204
ModifierTime 120–780 min 675.993 min
K sCyclinD 100–2000 ((molecules/cell)/min) 1761.08 ((molecules/cell)/min)
Cyclin D Initial Levels 10000–20000 (molecules/cell) 19264 (molecules/cell)