Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

Table 4 Reference model selection criteria

Model	Detailed pRb Phosphorylation steps modeling	Cyclin A levels modeling	Regulation of metabolism on the cell cycle execution modeling	Whole cell cycle machinery modeling	Referring to continuous growth factors exposure experiments	p16/p27 levels modeling	Availability in machine readable format
Yao et al. [60]	×	×	×	×	×	×/×	✓
Tyson and Novak [54] and Conradie et al. [55]	×	✓	✓	✓	×	×/✓	✓
Habericther et al. [40]	✓	✓	✓	×	✓	×/✓	✓
Swat et al. [59]	✓	×	×	×	×	×/×	✓
Iwamoto et al. (2008) [56]	✓	✓	×	×	-	✓/✓	×
Iwamoto et al. (2011) [57]	✓	✓	×	✓	-	✓/✓	×
Pfeuty [58]	✓	×	×	×	×	×/✓	×
Aguda and Tang [73]	×	×	×	×	-	✓/✓	✓

ISSN: 1752-0509