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Table 4 Reference model selection criteria

From: Differentiation resistance through altered retinoblastoma protein function in acute lymphoblastic leukemia: in silico modeling of the deregulations in the G1/S restriction point pathway

Model Detailed pRb Phosphorylation steps modeling Cyclin A levels modeling Regulation of metabolism on the cell cycle execution modeling Whole cell cycle machinery modeling Referring to continuous growth factors exposure experiments p16/p27 levels modeling Availability in machine readable format
Yao et al. [60] × × × × × ×/×
Tyson and Novak [54] and Conradie et al. [55] × × ×/
Habericther et al. [40] × ×/
Swat et al. [59] × × × × ×/×
Iwamoto et al. (2008) [56] × × - / ×
Iwamoto et al. (2011) [57] × - / ×
Pfeuty [58] × × × × ×/ ×
Aguda and Tang [73] × × × × - /
  1. - : not defined