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Fig. 2 | BMC Systems Biology

Fig. 2

From: The game theory of Candida albicans colonization dynamics reveals host status-responsive gene expression

Fig. 2

Competition between cells with or without EFG1. Colonization dynamics of mixed populations of C. albicans were measured in Ca-educated mice (black circles or triangles) or BALB/c nu/nu mice (open or grey circles or diamonds). Panels a, b, and c show the fraction of Δefg1 null mutant cells in either of the mixed populations in fecal pellets as a function of time. Each symbol indicates a sample from an individual mouse. Panel a: Competition between Δefg1 and ACT1pr-EFG1 cells. Closed circles, Ca-educated BALB/c mice. Open circles, BALB/c nu/nu mice. Panel b: Competition between Δefg1 and WT cells. Closed triangles, Ca-educated BALB/c mice. Open diamonds, BALB/c nu/nu mice. Grey diamonds, Ca-educated BALB/c nu/nu mice. Panel c: Competition between Δefg1 and WT cells. Open triangles, Ca-educated BALB/c mice treated with anti-CD4 antibody. Closed triangles, Ca-educated BALB/c mice treated with isotype control antibody. Panel d: Levels of C. albicans in fecal pellets collected on day 1, 6 or 18 post-inoculation from orally inoculated mice. Squares, WT C. albicans; circles, Δsin3 null mutant; triangles, Δsin3/SIN3 + complemented strain. Closed symbols, n-BALB/c mice; open symbols, BALB/c nu/nu mice

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