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Table 2 Parameters of the reduced model

From: Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Parameter Description Value Unit
\(C_{{g_A}}, C_{{g_B}}, C_{{g_C}}\) gA, gB, gC copy number - adim.
\(k_{{m_A}}, k_{{m_B}}, k_{{m_C}}\) gA, gB, gC transcription rate - min −1
\(d_{{m_A}}, d_{{m_B}}, d_{{m_C}}\) m A , m B , m C degradation rate 0.3624 min −1
\(k_{{p_A}}\) m A translation rate 80 min −1
\(k_{{p_B}}, k_{{p_C}}\) m B , m C translation rate - min −1
d A A degradation rate 0.035 min −1
d B ,d C B, C degradation rate - min −1
k d inducer diffusion rate 0.06 min −1
k 2, k 3 (AI) and (AI) 2 association rate 0.1 min −1
k −2 (AI) dissociation rate 20 min −1
k −3 (AI) 2 dissociation rate 1 min −1
γ 1 gB promoter Hill constant - nM
γ 2 gC promoter coefficients 0.2 nM
γ 3,γ 4,γ 5 gC promoter coefficients - adim, adim, nM −1
β 1,β 2 gC promoter basal expression coefficients 0.05 adim, nM −1
d I ,d Ie inducer degradation rate 0.0164 min −1
d AI ,d A I2 (AI), (AI) 2 degradation rate 0.035 min −1