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Table 4 Design guidelines. Each one of the optimized parameters is either a general guideline for all clusters, or is a trade-off control tuning knob for a specific cluster

From: Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Parameter Initial parameter range Design guideline
   General guideline Cluster 1 Cluster 2
kmACgA [1 200] [1 171.91] 1
kmBCgB [1 200] 1 [1 200]
kmCCgC [1 200] [1 171.91] 1
kpB [1 100] 1
kpC [1 100] [1 15.68] 1
dB [0.01 0.3] [0.01 0.0792]
dC [0.01 0.3] [0.2784 0.3] 0.3
γ 1 [50 200] [78.93 200]
γ 3 [1e-4 0.5] [1e-4 0.013] [1e-4 0.0141]
γ 4 [5e-4 5] [5e-4 1.4424] [0.0697 5]
γ 5 [1 100] [1 9.2546] [12.125 100]
  1. *kmACgA Is the same as kmCCgC as the are physically in the same plasmid