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Table 4 Design guidelines. Each one of the optimized parameters is either a general guideline for all clusters, or is a trade-off control tuning knob for a specific cluster

From: Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Parameter

Initial parameter range

Design guideline

  

General guideline

Cluster 1

Cluster 2

kmACgA

[1 200]

[1 171.91]

1

kmBCgB

[1 200]

1

[1 200]

kmCCgC

[1 200]

[1 171.91]

1

kpB

[1 100]

1

kpC

[1 100]

[1 15.68]

1

dB

[0.01 0.3]

[0.01 0.0792]

dC

[0.01 0.3]

[0.2784 0.3]

0.3

γ 1

[50 200]

[78.93 200]

γ 3

[1e-4 0.5]

[1e-4 0.013]

[1e-4 0.0141]

γ 4

[5e-4 5]

[5e-4 1.4424]

[0.0697 5]

γ 5

[1 100]

[1 9.2546]

[12.125 100]

  1. *kmACgA Is the same as kmCCgC as the are physically in the same plasmid