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Table 4 Design guidelines. Each one of the optimized parameters is either a general guideline for all clusters, or is a trade-off control tuning knob for a specific cluster

From: Multi-objective optimization framework to obtain model-based guidelines for tuning biological synthetic devices: an adaptive network case

Parameter Initial parameter range Design guideline
   General guideline Cluster 1 Cluster 2
kmACgA ∗ [1 200] – [1 171.91] 1
kmBCgB [1 200] – 1 [1 200]
kmCCgC [1 200] – [1 171.91] 1
kpB [1 100] 1 – –
kpC [1 100] – [1 15.68] 1
dB [0.01 0.3] [0.01 0.0792] – –
dC [0.01 0.3] – [0.2784 0.3] 0.3
γ 1 [50 200] [78.93 200] – –
γ 3 [1e-4 0.5] – [1e-4 0.013] [1e-4 0.0141]
γ 4 [5e-4 5] – [5e-4 1.4424] [0.0697 5]
γ 5 [1 100] – [1 9.2546] [12.125 100]
  1. *kmACgA Is the same as kmCCgC as the are physically in the same plasmid
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BMC Systems Biology

ISSN: 1752-0509

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