Skip to main content
Fig. 1 | BMC Systems Biology

Fig. 1

From: Comparing Alzheimer’s and Parkinson’s diseases networks using graph communities structure

Fig. 1

Experimental design. a Starting from the two induced networks, communities were calculated (blue circles) and for each of them a list of Gene Ontology terms was retrieved. b Communities term lists were compared calculating Jaccard similarity, which was then reported in a similarity matrix (red high overlap, blue low overlap). c The similarity matrix consists of communities that contain significant terms (Benjamini p-value <0.05). A clustering algorithm revealed areas (green squares) that represent common processes, while communities without any high overlap counterpart (blue long rectangles) were analyzed to find specific processes of the two pathologies d) Network topology was analyzed to assess structure overlap between pairs (Hamming distance) of communities concluding that topology implies biological process but not vice-versa. Clustered green areas were further analyzed by assigning to terms in the clusters a significance p-value

Back to article page