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Fig. 10 | BMC Systems Biology

Fig. 10

From: Molecular and cellular factors control signal transduction via switchable allosteric modulator proteins (SAMPs)

Fig. 10

The molecular properties of an enzymatic receptor shape the cellular response. The concentration of each enzymatic modulator protein is set to the level that optimizes the output dynamic range. a Graded and switch-like responses: The Hill coefficient computed from the normalized response curves differentiates between modulator proteins which produce graded and switch-like responses. b EC50 and c fractional receptor occupancy at the EC50 as a function of the enzymatic allostery αE and the relative affinity \( {\beta}_E \). Other parameters: [RT] = 10 μM, κ = k−1 = k2 = k−3 = k−4 = k−5 = 1 s−1, γ = 0.1 s−1 and k1 = k3 = 1 s−1 μM−1. k−3, k4, k5, k6 are given by the allosteric parameters and the requirement for detailed balance. The red dot indicates the location of the RapA-PhrA system from B. subtilis in the parametric design space of SAMPs

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