The allosteric class of an enzymatic SAMP affects its response behavior. a Mean response amplitude is plotted as a function of cooperativity by averaging over 104 different sets of Class II parameters. K
1R, ι and μ were varied between 0.1 and 10, and κ
in the range of 0.01 to 1 by Latin hypercube sampling. b Corresponding response entropy H.
c Cartoon summarizing the qualitative response behavior of the different classes of enzymatic modulators