Fig. 9

Conditions optimal for signaling amplitude. Relative response amplitudes A for three Rap-like SAMPs are plotted as a function of the modulator-to-regulator ratio μ and the relative kinase activity κ/γ. a Coherent enzyme with α _E  = 0.37 and α _B  = 5. b Enzyme without enzymatic allostery (α _E  = 1). c Enzyme without binding allostery (α _B  = 1). Other parameters: [R_T] = 2 μM, K_M = 1.2 μM, k₂ = 0.72 s⁻¹, γ = 1.2*10⁻⁴ s⁻¹