Fig. 2

HGSOCr molecular model. a Each node represents a molecular process, the node diameter scales with the number of protein coding genes included. Edges between molecular processes indicate a significant number of protein-protein interactions between protein coding genes across molecular processes. Color-coding scales with the sum of individual biomarker frequencies in LASSO selection based on bootstrap runs of the transcript feature set classifier for explaining variance in PFS. b Subgraph representation of molecular process 4. Each node codes for a protein coding gene, edges represent interactions according to the underlying interaction network. Genes of specific relevance are highlighted in red (VEGFA, mTOR, CCND1)