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Fig. 2 | BMC Systems Biology

Fig. 2

From: Hypothetical biomolecular probe based on a genetic switch with tunable symmetry and stability

Fig. 2

Deterministic stability diagrams for generic asymmetric switch. a s 1 vs. s 2 for varying values of β 1=β 2=β={2,3,100,900}(nM−1). Bistability region is inside the curves. b β 1 vs. β 2 for varying values of s 1=s 2=s={0.002,0.01,0.03,0.1}. Bistability region is enclosed by the curves. c s 2 vs. β 2. s 1 and β 1 are held at 0.01 and 17.5 respectively. The dotted black line encloses the deterministically determined bistable region. A stochastically determined joint bistable region (bistable with switching) is represented as as heat plot in colors from purple to red. The heat bar represents the switching frequency in Hz. The black region in the middle represents bistability where no switching occurred for the duration of the simulation of (2×103 seconds)

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