Table 1 Parametric sensitivity analysis of the complete model for GLUT4 membrane translocation
Parameter | Complete model | wo_feedback p70S6K | wo_feedback ERK1/2 | Process |
|---|---|---|---|---|
k_13 | −84.89 % | −83.59 % | −84.89 % | GLUT4 translocation |
k13p | 66.02 % | 66.76 % | 66.02 % | GLUT4 translocation |
k13 | 19.03 % | 17.01 % | 19.03 % | GLUT4 translocation |
n_p70 | −15.21 % | - | −15.21 % | p70 mediated IRS1 phosphorylation at Ser |
k9a | 8.25 % | 13.87 % | 8.25 % | lipids PI(3,4,5)P3 formation |
k9s | −8.25 % | −13.86 % | −8.25 % | lipids PI(3,4,5)P3 formation |
k8 | 7.36 % | 10.88 % | 7.36 % | IRS1_PI3K complex formation |
k_8 | −7.36 % | −10.87 % | −7.35 % | IRS1_PI3K complex formation |
k_14 | −5.25 % | −5.19 % | −5.25 % | GLUT4 degradation |
k_7 | −5.05 % | −2.68 % | −5.05 % | IRS1 dephosphorylation at Tyr |
k7 | 5.05 % | 2.68 % | 5.05 % | IRS1 phosphorylation at Tyr |
k_7p | 4.45 % | 0.53 % | 4.45 % | IRS1 dephosphorylation at Ser |
k15 | −4.30 % | - | −4.30 % | IRS1 phosphorylation by P70S6K |
Kd_p70 | 0.72 % | - | 0.72 % | p70 mediated IRS1 phosphorylation at Ser |
Vmax | 0.65 % | 2.18 % | 0.65 % | PKC and p70 mediated IRS1 phosphorylation at Ser |
k4p | −0.51 % | −0.27 % | −0.52 % | Phosphorylated receptor internalization |
k_21 | −0.18 % | - | −0.18 % | TSC1-TSC2 T1462_phosphorylation_by_Akt_pT309 |
k7p | −0.15 % | −0.54 % | −0.15 % | IRS1 phosphorylation at Ser |
k41 | 0.14 % | 0.46 % | 0.14 % | IRS1-GS and IRS1-SHP2 complex disruption |