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Fig. 5 | BMC Systems Biology

Fig. 5

From: Evaluation of rate law approximations in bottom-up kinetic models of metabolism

Fig. 5

Kinetic properties of models sampled with models sampled with physiological concentrations and fluxes compared to models sampled in wider ranges of concentrations and fluxes. First, 63 models were built with metabolite concentrations and fluxes sampled from physiologically relevant range. Then, 23 models were constructed with a wider range of metabolite concentrations (10−8 to 105 mM) and fluxes. ATP hydrolysis was chosen as a reference perturbation as the perturbation on all models and RT and MP of the metabolites was calculated. a Distribution of pair-wise Pearson correlation coefficients of metabolite RTs for models sampled with wider concentration and flux ranges and models sampled with physiologically relevant ranges. b Distribution of pair-wise Pearson correlation coefficients of metabolite MPs for models sampled with wider concentration and flux ranges and models sampled with physiologically relevant ranges. c Distribution of metabolite RTs for models sampled with wider concentration and flux ranges. d Distribution of metabolite MPs for models sampled with wider concentration and flux ranges. The sampling and simulations were performed on the whole-cell kinetic model of erythrocyte constructed by Bordbar et al [33]

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