Fig. 6
From: Evaluation of rate law approximations in bottom-up kinetic models of metabolism
Reaction properties affecting the impact of reaction rate law approximations. a Enzyme substitution impact (rank) against reaction thermodynamic irreversibility (Log10). Reaction thermodynamic irreversibility is calculated as (reaction equilibrium constant - mass action ratio)/reaction equilibrium constant. Lower rank score meant less change in dynamic response when the module is replaced by mass action kinetics. Reactions highlighted in red indicate presence of regulation. Circled reactions are outliers of the general trends. PGLASE is irreversible but shows low impact upon reaction rate law approximation. GSSGR has a large substrate concentration, yet still shows significant impact upon reaction rate law approximation. b Enzyme substitution impact (rank) against largest metabolite concentration in the reaction. Red and circled reactions are the same as in panel (a). The simulations were performed on the model constructed based on Mulquiney et al [34]