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Table 1 General description of the constructed enzyme modules

From: Evaluation of rate law approximations in bottom-up kinetic models of metabolism

Enzyme name Module size (metabolites × reactions) Regulators (mechanism of action)
Phosphogluconate dehydrogenase (GND) 13 × 9 NADPH (PI)
Lactate dehydrogenase (LDH) 10 × 6 N/A
Glucose-6-phosphate dehydrogenase (G6PDH) 12 × 7 ATP (CI), NADPH (PI)
Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) 27 × 27 3PG (AI), G3P (AI)
Hexokinase (HEX1) 10 × 6 23DPG (CI)
Pyruvate kinase (PK) 30 × 34 FDP (AA), ATP (PI, AI)
Phosphofructokinase (PFK) 40 × 44 ADP (PI), ATP (AI), AMP (AA)
Phosphoglycerate kinase (PGK) 13 × 9 ATP (PI), 3PG (PI), 23DPG (CI)
Adenylate kinase (ADK) 8 × 5 N/A
Glucose-6-phosphate isomerase (PGI) 5 × 3 N/A
  1. PI product inhibitor, AI allosteric inhibitor, AA allosteric activator, CI competitive inhibitor