Fig. 9

RB/E2F map. This map represents the regulation of the cell cycle by E2F/RB. The cell cycle is a succession of four phases (G1, S, G2 and M phases) that are tightly regulated by so-called pocket proteins, whose main representative is the RB protein. The RB protein major function is to inhibit transcription factors belonging to the E2F family, and in particular the E2F1 protein. Diverse cyclin dependent kinases (CDKs) play a key role in the regulation of the cell cycle. In particular, CDKs’ function is to phosphorylate the RB protein, decreasing its inhibiting effect on E2F transcription factors. This map is represented using the SBGN-PD language. EPNs with bold borders constitute the initial state of the map. Every colored EPN belongs to a story, and each color is assigned to a different story