Fig. 3

ANIMO model of the circadian clock in Drosophila Melanogaster. a The topology of the ANIMO model is the same as the model in [19]. Negative self-feedback loops are present on each of the nodes of the network to ensure that protein levels decrease over time when activating inputs are absent. This describes the normally occurring degradation of proteins in a similar way to what is done in the original ODE model. The feedback loops are represented in a lighter gray colour to enhance readability. b–e Comparing the result of the ANIMO model of Drosophila Melanogaster circadian clock with the model of [19]. 24 hours simulations of the two models were compared against each other, synchronizing their start point as much as possible. The blue line is the ANIMO model (_ANIMO series), while the red line represents the data computed from the original ODE model (_ODE series) using Matlab®;. The activity levels of the _ANIMO series were manually rescaled on a [0, 100] interval, to reflect what is done in the ODE model and thus facilitate comparison. Naming conventions follow the same rules as in [19], with lower-case names representing mRNA, and upper-case names indicating proteins