Fig. 8
From: Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle
The pathway used for oxidative stress alleviation in Plasmodium falciparum-infected human red blood cells. a The pathway used by P. falciparum-infected red blood cells (RBCs) to deal with oxidative stresses. b Metabolic fluxes through the reactions of GSHox, G6PD, and RU5Pt within infected and cocultured RBCs, i.e., uninfected RBCs cocultured with infected RBCs. c GSHox fluxes within G6PD-sufficient (wild type) and G6PD-deficient RBCs. cRBCs, un-infected RBCs co-cultured with iRBCs; G6PD, glucose 6-phosphate dehydrogenase; GSH, reduced glutathione; GSHox, the GSH-based oxidative stress alleviation; GSSG, oxidized glutathione; iRBCs, P. falciparum 3D7-infected RBCs in the infected RBC culture; RU5Pt, the transport of ribulose 5-phosphate from iRBCs into the medium