Metabolic host responses to malarial infection during the intraerythrocytic developmental cycle

BMC Systems Biology

Table 1 Mean and standard deviation of Pearson correlation coefficients of reaction fluxes and metabolic gene expression data between different strains (HB3, 3D7, and Dd2) of Plasmodium falciparum

Comparison	Metabolic flux correlation coefficient		Metabolic gene expression correlation coefficient
Comparison	Mean	Standard deviation	Mean	Standard deviation
HB3 vs. 3D7	0.55	0.24	0.62	0.26
HB3 vs. Dd2	0.52	0.24	0.72	0.25
3D7 vs. Dd2	0.68	0.23	0.76	0.26

A flux correlation coefficient was determined as the Pearson correlation coefficient between each strain pair’s time-series fluxes for each of the 530 reactions that were associated with non-constant fluxes. Similarly, we calculated gene expression correlation coefficients for the metabolic genes as the Pearson correlation coefficient between time-series expression data for each pair of strains. All pairwise strain differences between fluxes and gene expressions are statistically significant with p-values < 10⁻⁴

ISSN: 1752-0509