Fig. 5

Context-specific sub-network. Four embryonic stem cells (ES) and four T-cell DDRNs derived from the mouseENCODE open chromatin experiments with two to four replicates were intersected with a well studied stem cell related regulatory sub-network consisting of four pluripotency transcription factors (SOX2, NANOG, KLF4 and POU5F1) using the Network Browser in croco-web. The figure shows the fraction of the interactions of the selected sub-network found in the ES and T-cell DDRNs. The automatically generated croco-web plot for this use case shows that almost all regulations from the selected sub-network can be found in the ES-cell DDRNs, but only very few regulations can be found in the T-cells DDRNs