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Table 2 Top 20 metabolites that are significantly associated with cognitive decline in AD

From: Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

Metabolite Enrichment P value Literature
  fold   
d-proline 28.7 1.50E-39 [26]
1,2,3-propanetricarboxylic acid 19.1 8.45E-39  
5-aminopentanoic acid 12.1 1.80E-37  
chenodeoxycholic acid 8.5 6.29E-36 [27]
glycine conjugate    
cadaverine 7.66 2.42E-35 [28]
benzoyl-coa 7.66 2.42E-35  
diaminopimelic acid 5.9 1.45E-33  
putrescine 4.9 5.85E-32 [28]
trehalose 4.7 1.49E-31  
succinic acid 4.6 2.37E-31 [23]
5-methylthioribulose 1-phosphate 4.4 6.05E-31  
pyrrolidine 4.2 2.49E-30 [32]
citramalic acid 4.0 6.42E-30  
trans-ferulic acid 3.8 4.30E-29 [2931]
mannitol 3.5 2.91E-28 [22]
4-hydroxybenzoic acid (DOPAC) 3.6 2.91E-28 [24]
d-glutamic acid 3.4 7.60E-28 [35]
melibiose 3.3 1.99E-27  
5alpha-cholestanol 3.3 3.24E-27 [33, 34]
1-butanol 3.0 9.63E-26  
  1. The three known metabolites (mannitol, succinic acid, and DOPAC) are highlighted