Table 3 Top nine ranked genetic pathways associated with AD (biomarkers), TMAO and both
From: Towards understanding brain-gut-microbiome connections in Alzheimer’s disease
AD | TMAO | AD ∩TMAO |
|---|---|---|
(27 pathways) | (171 pathways) | (9 pathways) |
Lipoprotein metabolism | Cysteine and methionine metabolism | Metabolism of proteins |
Metabolism of lipids and lipoproteins | Pyruvate metabolism | Immune system |
Axon guidance | Glycolysis / Gluconeogenesis | Adaptive immune system |
Alzheimer’s disease | Propanate metabolism | Alzheimer’s disease |
Amyotrophic lateral sclerosis (ALS) | Transcription | Axon guidance |
Mitochondrial Protein Import | Amyloids | Amyotrophic lateral sclerosis (ALS) |
Cell junction organization | The citric acid (TCA) cycle and respiratory electron transport | EPHA forward signaling |
HDL-mediated lipid transport | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription | EPHB forward signaling |
Lipid digestion, mobilization, and transport | Splicesome | Metabolism of lipids and lipoproteins |