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Table 3 Top nine ranked genetic pathways associated with AD (biomarkers), TMAO and both

From: Towards understanding brain-gut-microbiome connections in Alzheimer’s disease

(27 pathways) (171 pathways) (9 pathways)
Lipoprotein metabolism Cysteine and methionine metabolism Metabolism of proteins
Metabolism of lipids and lipoproteins Pyruvate metabolism Immune system
Axon guidance Glycolysis / Gluconeogenesis Adaptive immune system
Alzheimer’s disease Propanate metabolism Alzheimer’s disease
Amyotrophic lateral sclerosis (ALS) Transcription Axon guidance
Mitochondrial Protein Import Amyloids Amyotrophic lateral sclerosis (ALS)
Cell junction organization The citric acid (TCA) cycle and respiratory electron transport EPHA forward signaling
HDL-mediated lipid transport RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription EPHB forward signaling
Lipid digestion, mobilization, and transport Splicesome Metabolism of lipids and lipoproteins