Fig. 4

Hematopoietic differentiation blockade validated by reduction folds in different stem and progenitor subsets in the hematopoietic cascade. a Computational decomposition of the HPC dynamics on relevant processes. HPC generation (ie HSC differentiation into HPC – HSC- > HPC, red), HPC differentiation (Diff, green) and death (Death, blue). b Absolute numbers of HSCs differentiating towards HPCs in consecutive time intervals simulated by the computational model. T _i is [day i-1, day i] for i = 1, 2, …, 21. c Reduction folds in different HSC/HPC subsets (upper panel) and an experimental schema (lower panel) showing the differentiation block from HSCs to HPCs. Numbers −5, −29, etc. indicate the fold decrease [11]