Fig. 5
From: Digitalization of a non-irradiated acute myeloid leukemia model
Comparisons of model fitness between systematic and individual modelings. a Inferior fitness of the plain models for the spleen cell kinetics, which ignore the inter-connections between tissues (cell mobility, CM = 0) or overlooking them as a constant (CM = const) unrelated with PB kinetics. d 1,1 , d 1,2 - fitness degrees for leukemic kinetics when CM = 0 and const, respectively; d 2,1 , d 2,2 - fitness for normal cell kinetics when CM = 0 and const. s 1,2 , Sample standard deviation (s 1 - leukemic, s 2 - normal). b Box plots illustrate a significantly higher fitness of the model including the CM as a function of PB kinetics (ie CM = f(L,N), L - PB leukemic cells, N - PB normal cells) for the spleen cell kinetics (one-tail t-test, ** p < 0.005). c Inferior fitness of the plain models ignoring or overlooking cell mobility for the BM cell kinetics. d Significantly higher fitness of the model including CM as a function of PB kinetics for the BM cell kinetics (one-tail t-test, *** p < 0.001)