Fig. 6

Parametric analyses for differential cell kinetics in PB, spleen and BM. a Action rates of normal cells at the tissue-level (ie total CD45.1⁺ cells) in PB during leukemia development. As primitive blood cells rarely occur in PB circulation, the PB cells are regarded as having no proliferation. b Actions rates of normal cells in spleen during leukemia development. Upper panel: proliferation and death rates for total CD45.1⁺ cells in spleen; lower panel: cell export and import rates; red arrow: time point when the number of spleen CD45.1⁺ cells reaches maximal. c Actions rates of normal cells in BM during leukemia development. Upper panel: proliferation and death rates for total CD45.1⁺ cells in BM; lower panel: cell export and import rates