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Table 1 Performance of prediction scores in the DREAM dataset

From: A simple gene set-based method accurately predicts the synergy of drug pairs

Scoring methods PC-index P-value
Co-gene score \( \frac{g_{d_1,{d}_2}}{G} \) 0.648 <0.0001
Co-GS score \( \frac{n_{d_{1,}{d}_2}}{L} \) 0.589 0.0036
Co-gene/GS score \( \frac{{\displaystyle {\sum}_l}\frac{N_{d_1,{d}_2}^l}{N^l}}{n_{d_{1,}{d}_2}} \) 0.663 <0.0001
  1. Notations: \( {g}_{d_1,{d}_2} \), number of commonly regulated genes between drugs \( {d}_1 \) and \( {d}_2 \); \( G \), total number of genes; \( {n}_{d_{1,}{d}_2} \), number of gene sets with significant enrichment in both drugs; \( L \), total number of gene sets; \( {N}_{d_1,{d}_2}^l \), number of genes with significantly changes in both drug treatments within a co-enriched gene set l