Fig. 6

The pulses of p53 pathway. Expression levels of four genes in the major switch of P53 pathway lead to pulse diagram. The high expression level of a gene presents Boolean value ‘1’ while low expression level means Boolean value ‘0’. Expression levels of each node also lead to a specific integrated state in the time transition diagram. The four different pulse lines, which are ATM (black solid line), p53 (blue solid line), Wip1 (green solid line), Mdm2 (red solid line), show cyclic changes after 10 sec