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Fig. 2 | BMC Systems Biology

Fig. 2

From: Stochastic modeling suggests that noise reduces differentiation efficiency by inducing a heterogeneous drug response in glioma differentiation therapy

Fig. 2

Ultrasensitive response of cyclin D1 controls the phenotypic transition of drug-induced glioma differentiation. a The sensitivity analysis revealed that cyclin D1 critically regulates glioma differentiation. b Activation levels of cyclin D1 and GFAP under treatment with increasing doses of CT for 48 h. Lines represent simulations (green - cyclin D1; red - GFAP), and dots are experimental data (blue - cyclin D1; brown - GFAP). The apparent Hill coefficients (n H ) of the simulated dose-response curves of cyclin D1 and GFAP are 40 and 43, respectively, indicating an ultrasensitive response of glioma differentiation to drug treatment. c Time-courses of cyclin D1 (green) and GFAP (red) following drug treatment (CT = 10 ng/ml)

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