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Fig. 4 | BMC Systems Biology

Fig. 4

From: Tailored parameter optimization methods for ordinary differential equation models with steady-state constraints

Fig. 4

Illustration of the simulation-based optimization method for the conversion process (20). a Trajectory of the continuous analogue for different retraction factors λ (full lines), the endpoints (stars), the true optimum (red star), and the steady-state manifold (surface, (21)) are shown. The objective function values are indicated by the surface coloring. b The distance to the analytical steady state as well as c, d the path of the parameters (full lines), their endpoints (stars) and optimal parameter value (dotted lines) are depicted

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