Fig. 3
From: Drug combinatorics and side effect estimation on the signed human drug-target network
Coherent/mixed/incoherent length-4 cycles. Two drugs having two targets in common in a signed graph. In panel a all 3 cases lead to an (undirected) positive cycle, and the drug actions are coherent at each target. In panel b instead, the length-4 (undirected) cycle is negative, and the action of the drugs is incoherent on one of the two targets but coherent on the other. In panel c the action of the drugs is incoherent on each target, but the cycle is positive