Fig. 5
From: Drug combinatorics and side effect estimation on the signed human drug-target network
Synergistic scores for drug pairs and pharmacological targets. The histogram shows the distribution of synergistic score coefficients for drug pairs sharing one or more pharmacological targets and no off-targets. When a i (j)>0 and a j (i)>0, the two drugs induce a benefit on each other’s pharmacological targets, i.e., the number of coherent action pairs is bigger than the number of incoherent ones (81.6 % of the cases)