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Table 2 Drug modes of action and edge signs

From: Drug combinatorics and side effect estimation on the signed human drug-target network

Sign

DrugBank actions

Positive

agonist; partial agonist; activator; stimulator; inducer;

 

positive allosteric modulator; potentiator; positive modulator

Negative

inhibitor; inhibitory allosteric modulator; inhibitor, competitive; antagonist; partial antagonist; negative modulator; inverse agonist; blocker; suppressor; desensitize the target; neutralizer; reducer

Not classifiable

antibody; cofactor; modulator; binder; chaperone; cleavage; metabolizer; ligand; product of; component of; chelator; cross-linking/alkylation; intercalation; adduct; acetylation; allosteric modulator.