Skip to main content

Table 2 Nominal model parameter values

From: Metabolic modeling of a chronic wound biofilm consortium predicts spatial partitioning of bacterial species

Parameter Description Value Source
W Biofilm thickness 80 μm Specified
G b Bulk glucose concentration 7.5 mmol/L [75]
O a Oxygen concentration at the biofilm-air interface 0.21 mmol/L [103]
O b Oxygen concentration at the tissue-biofilm interface 0 mmol/L Specified
A b Bulk acetate concentration 0 mmol/L Specified
S b Bulk succinate concentration 0 mmol/L Specified
L b Bulk lactate concentration 1.0 mmol/L [75]
P b Bulk pyocyanin concentration 0 mmol/L Specified
\( {k}_{dX} \) , \( {k}_{dY} \) Death rate constants 0–0.01 h−1 Calculated
k L Pyocyanin-associated death rate constant 0.4 mmol/gDW/h Specified
k dP Pyocyanin flux bound 0.1 L/mmol/h Specified
Z max Maximum biomass concentration 200 g/L [46]
km G , km A , km S , km L , km P Mass transfer coefficients for glucose, acetate, succinate, lactate and pyocyanin 2.0 × 10−4 cm/s Specified
D WG Aqueous diffusion coefficient for glucose 9.4 × 10−6 cm2/s [67]
D WO Aqueous diffusion coefficient for oxygen 26.8 × 10−6 cm2/s [67]
D WA Aqueous diffusion coefficient for acetate 16.2 × 10−6 cm2/s [67]
D WS Aqueous diffusion coefficient for succinate 12.6 × 10−6 cm2/s [67]
D WL Aqueous diffusion coefficient for lactate 12.1 × 10−6 cm2/s [104]
D WP Aqueous diffusion coefficient for pyocyanin 7.2 × 10−6 cm2/s Specified
a G , a S , a L , a P Adjustable parameter for glucose, succinate, lactate and pyocyanin in Eq. (6) 0.33 Fitted
a O Adjustable parameter for oxygen in Eq. (6) 0.19 Fitted
a A Adjustable parameter for acetate in Eq. (6) 0.36 Fitted
X 0 , Y 0 Initial biomass concentrations 1 g/L Specified
k A Aerotaxis rate constant 5 × 10−8 cm2. L/mmol. s Specified
km O Oxygen mass transfer coefficient 2.0 × 10−2 cm/s Specified
Back to article page