Metabolic modeling of a chronic wound biofilm consortium predicts spatial partitioning of bacterial species

BMC Systems Biology

Table 3 Lexicographic objective functions

Number	Species	Direction	Objective	Reason
1	PA	Maximize	Growth rate	Assumed primary objective
1	SA	Maximize	Growth rate	Assumed primary objective
2	PA	Minimize	Acetate secretion flux	Minimize byproduct synthesis
2	SA	Minimize	Acetate secretion flux	Minimize byproduct synthesis
3	PA	Minimize	Succinate secretion flux	Minimize byproduct synthesis
3	SA	Minimize	Lactate secretion flux	Minimize byproduct synthesis
4	PA	Maximize	Glucose uptake flux	Maximize nutrient consumption
4	SA	Maximize	Glucose uptake flux	Maximize nutrient consumption
5	PA	Maximize	Oxygen uptake flux	Maximize nutrient consumption
5	SA	Maximize	Oxygen uptake flux	Maximize nutrient consumption
6	PA	Maximize	Lactate uptake flux	Maximize consumption of putative cross-fed metabolite
6	SA	Maximize	Succinate uptake flux	Maximize consumption of putative cross-fed metabolite

ISSN: 1752-0509