Table 1 Summary of targets validated
From: The effect of inhibition of PP1 and TNFα signaling on pathogenesis of SARS coronavirus
Rank | Network Bottleneck | Network hub | WGCNA | Differential expression** |
|---|---|---|---|---|
1 | *Stat1 | *Ccr5 | *Myd88 | Cxcr3 |
2 | *Ccr5 | *Myd88 | *Ccr5 | *Ccr5 |
3 | *Myd88 | *Stat1 | Cxcr3 | *Serpine1 |
4 | *Kepi | *Kepi | *Stat1 | *Ccr1 |
5 | *Serpine1 | Cxcr3 | *Kepi | Ido1 |
6 | *Ccr1 | Ido1 | Ido1 | Plat |
7 | Cxcr3 | *Ccr1 | Plat | *Stat1 |
8 | Plat | *Serpine1 | *Serpine1 | Il1r1 |
9 | Ido1 | Il28ra | Il28ra | Il18r1 |
10 | Ptges2 | Plat | *Ccr1 | *Ccr2 |
11 | Il1r1 | *Ccr2 | *Ccr2 | *Myd88 |
12 | Il28ra | Ptges2 | Il18r1 | Ifnar |
13 | *Ccr2 | Il1r1 | Ptges2 | Il28ra |
14 | Ifnar | Il18r1 | Il1r1 | Ptges2 |
15 | Il18r1 | Ifnar | Ifnar | *Kepi |