Fig. 3
From: Attractor landscape analysis of colorectal tumorigenesis and its reversion
The change of attractor basin along with the sequential accumulation of driver mutations during colorectal tumorigenesis. a The basin size of a normal proliferation attractor. The basin size of a normal proliferation attractor was decreased by KRAS and TP53 mutations. b The basin size of an abnormal proliferative phenotype attractor. The basin size of an abnormal proliferative phenotype attractor was significantly increased by KRAS mutation. c The basin size of a cancer progression attractor. The basin size of a cancer progression attractor was increased by KRAS mutation. d The basin size of a metastatic phenotype attractor. The basin size of a metastatic phenotype attractor shows an increasing tendency by sequential accumulation of driver mutations. In particular, the mutations of KRAS and TP53 dramatically increased the size of a metastatic phenotype attractor