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Fig. 3 | BMC Systems Biology

Fig. 3

From: Combining laboratory and mathematical models to infer mechanisms underlying kinetic changes in macrophage susceptibility to an RNA virus

Fig. 3

Susceptibility and CD163 dynamics. Batch specific least square mean (LSM) percentages and standard errors obtained from the experimental data (ac) and from the predictions of model B (df) obtained by linear mixed model analysis. Batches 1 and 3 consisted of three biological replicates (i.e. cells from three different pigs), and batch 2 comprised two biological replicates. The estimates refer to the proportion of PAMs classified as infected (a & d), CD163 positive (b & e), and CD163 positive within the set of infected cells (c & f), after incubation for 0, 1, 2, 4, 6, 8 and 9 days, respectively, before PRRSV (infected) or mock-infection (control). Estimates refer to 18 h post (mock) infection. Predictions refer to refined model B with assumption AS1 (i.e. switching rates independent of CD163, σ1,max = σ2,max = σmax)

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