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Fig. 5 | BMC Systems Biology

Fig. 5

From: Combining laboratory and mathematical models to infer mechanisms underlying kinetic changes in macrophage susceptibility to an RNA virus

Fig. 5

Schematic figure of model B. Components in blue and green refer to the cell types and biological processes represented at all stages of the experiment (i.e. prior and post infection with the PRRS virus or the mock agent). Components in red show additional cell types and processes after introduction of the virus into the cell cultures. C and C + represent PAMs without/with the CD163 receptor on the cell surface, and M and M + represent the non-susceptible and susceptible state, respectively. Cells indicated with ‘*’ denote infected cells. The bottom right panel illustrates the dependence of the switching rates σi+− and σi−+ on the compound F (for parameter values F T  = 1000, ε = 0.1, σmax = 0.9). See main text for more detailed description of the model, Additional file 4 for the mathematical representation of the model, and Additional file 5 for a description of the model parameters

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