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Table 2 Estimated parameter values (with standard errors) for model B, assuming σ1,max = σ2,max = σmax

From: Combining laboratory and mathematical models to infer mechanisms underlying kinetic changes in macrophage susceptibility to an RNA virus

Pig

Pig 1

Pig 2

Pig 3

Pig 4

Pig 5

Pig 6

Pig 7

Pig 8

Batch (B)/Parameters

B1

B1

B1

B2

B2

B3

B3

B3

δ1

3.5E-5

2.4E-5

0.0027

0.0094

0.079

0.108

0.0633

1.0E-4

(0.007)

(0.015)

(0.006)

(0.0075)

(0.011)

(0.020)

(0.002)

(0.003)

δ2

0.0041

0.053

0.049

0.0030

0.0061

0.011

0.0057

0.0047

(0.001)

(0.034)

(0.006)

(0.0009)

(0.0017)

(0.011)

(0.021)

(0.024)

σmax

0.17

0.015

0.022

0.072

0.0056

1.0E-5

1.0E-9

5.1E-11

(0.11)

(0.013)

(0.012)

(0.004)

(0.0089)

(0.0065)

(0.0012)

(0.0049)

FT

1.5E6

5.5E6

7.4E6

1.8E6

1.4E6

1.0E6

8.3E5

7.1E6

(3.1E5)

(5.3E6)

(6.1E5)

(2.6E5)

(2.5E5)

(6.3E6)

(3.3E7)

(5.3E7)

μ1

0.0021

0.015

0.014

0.003

0.022

0.028

0.086

0.11

(0.026)

(0.003)

(0.002)

(0.015)

(0.028)

(0.031)

(0.005)

(0.021)

μ2

0.144

0.036

0.031

0.15

0.20

0.135

0.14

0.11

(0.0052)

(0.012)

(0.014)

(0.006)

(0.039)

(0.050)

(0.014)

(0.018)

μ3

4.9E-4

0.073

0.012

0.0030

3.5E-6

3.1E-7

1.0E-8

1.7E-10

(6.5E-4)

(0.019)

(0.045)

(0.0015)

(5.7E-5)

(0.0017)

(0.023)

(0.026)

μ4

0.0070

0.014

0.0046

0.011

0.015

0.038

0.029

0.033

(0.0015)

(0.052)

(0.014)

(0.0009)

(0.0049)

(0.022)

(0.020)

(0.014)

c1

0.00048

0.024

0.061

0.0089

0.0030

0.66

0.91

0.33

(0.00044)

(0.13)

(0.170)

(0.023)

(0.0056)

(0.19)

(0.044)

(0.065)

c2

0.68

0.47

0.58

0.44

0.51

0.059

1.4E-5

0.58

(0.05)

(0.44)

(0.063)

(0.058)

(0.11)

(0.12)

(0.040)

(0.037)

c3

0.099

0.50

0.36

0.34

0.22

0.040

0.012

0.011

(0.008)

(0.19)

(0.48)

(0.015)

(0.010)

(0.012)

(0.004)

(0.003)

β1

0.94

0.99

1.00

0.54

0.31

0.20

0.24

0.21

(0.10)

(2.89)

(1.50)

(0.030)

(0.019)

(0.022)

(0.015)

(0.044)

β2

0.76

0.18

1.00

1.00

0.40

0.29

0.31

0.37

(0.025)

(0.18)

(0.54)

(0.042)

(0.070)

(0.12)

(0.054)

(0.080)

α3

0.63

0.98

1.00

0.53

0.77

0.40

0.36

0.31

(0.38)

(0.03)

(0.04)

(0.0097)

(0.017)

(0.031)

(0.017)

(0.027)

α4

0.53

0.05

0.092

0.38

0.39

0.28

0.32

0.26

(0.064)

(0.023)

(0.113)

(0.023)

(0.058)

(0.101)

(0.024)

(0.023)

  1. Parameter values are given up to two significant digits. Standard errors were derived from the covariance matrix of the weighted least square estimates as described in Additional file 2