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Table 2 Estimated parameter values (with standard errors) for model B, assuming σ1,max = σ2,max = σmax

From: Combining laboratory and mathematical models to infer mechanisms underlying kinetic changes in macrophage susceptibility to an RNA virus

Pig Pig 1 Pig 2 Pig 3 Pig 4 Pig 5 Pig 6 Pig 7 Pig 8
Batch (B)/Parameters B1 B1 B1 B2 B2 B3 B3 B3
δ1 3.5E-5 2.4E-5 0.0027 0.0094 0.079 0.108 0.0633 1.0E-4
(0.007) (0.015) (0.006) (0.0075) (0.011) (0.020) (0.002) (0.003)
δ2 0.0041 0.053 0.049 0.0030 0.0061 0.011 0.0057 0.0047
(0.001) (0.034) (0.006) (0.0009) (0.0017) (0.011) (0.021) (0.024)
σmax 0.17 0.015 0.022 0.072 0.0056 1.0E-5 1.0E-9 5.1E-11
(0.11) (0.013) (0.012) (0.004) (0.0089) (0.0065) (0.0012) (0.0049)
FT 1.5E6 5.5E6 7.4E6 1.8E6 1.4E6 1.0E6 8.3E5 7.1E6
(3.1E5) (5.3E6) (6.1E5) (2.6E5) (2.5E5) (6.3E6) (3.3E7) (5.3E7)
μ1 0.0021 0.015 0.014 0.003 0.022 0.028 0.086 0.11
(0.026) (0.003) (0.002) (0.015) (0.028) (0.031) (0.005) (0.021)
μ2 0.144 0.036 0.031 0.15 0.20 0.135 0.14 0.11
(0.0052) (0.012) (0.014) (0.006) (0.039) (0.050) (0.014) (0.018)
μ3 4.9E-4 0.073 0.012 0.0030 3.5E-6 3.1E-7 1.0E-8 1.7E-10
(6.5E-4) (0.019) (0.045) (0.0015) (5.7E-5) (0.0017) (0.023) (0.026)
μ4 0.0070 0.014 0.0046 0.011 0.015 0.038 0.029 0.033
(0.0015) (0.052) (0.014) (0.0009) (0.0049) (0.022) (0.020) (0.014)
c1 0.00048 0.024 0.061 0.0089 0.0030 0.66 0.91 0.33
(0.00044) (0.13) (0.170) (0.023) (0.0056) (0.19) (0.044) (0.065)
c2 0.68 0.47 0.58 0.44 0.51 0.059 1.4E-5 0.58
(0.05) (0.44) (0.063) (0.058) (0.11) (0.12) (0.040) (0.037)
c3 0.099 0.50 0.36 0.34 0.22 0.040 0.012 0.011
(0.008) (0.19) (0.48) (0.015) (0.010) (0.012) (0.004) (0.003)
β1 0.94 0.99 1.00 0.54 0.31 0.20 0.24 0.21
(0.10) (2.89) (1.50) (0.030) (0.019) (0.022) (0.015) (0.044)
β2 0.76 0.18 1.00 1.00 0.40 0.29 0.31 0.37
(0.025) (0.18) (0.54) (0.042) (0.070) (0.12) (0.054) (0.080)
α3 0.63 0.98 1.00 0.53 0.77 0.40 0.36 0.31
(0.38) (0.03) (0.04) (0.0097) (0.017) (0.031) (0.017) (0.027)
α4 0.53 0.05 0.092 0.38 0.39 0.28 0.32 0.26
(0.064) (0.023) (0.113) (0.023) (0.058) (0.101) (0.024) (0.023)
  1. Parameter values are given up to two significant digits. Standard errors were derived from the covariance matrix of the weighted least square estimates as described in Additional file 2
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BMC Systems Biology

ISSN: 1752-0509

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