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Fig. 8 | BMC Systems Biology

Fig. 8

From: DGCA: A comprehensive R package for Differential Gene Correlation Analysis

Fig. 8

Differential correlations between the genes in the p53 pathway in p53 non-mutated and p53-mutated breast cancer samples. The top panel shows a histogram of the correlation values pooled between both conditions that also demonstrates the color schema used to indicate the expression correlation strength for each gene pairs. The bottom panel shows a heatmap of correlation values in the two conditions. The bottom left panel shows the correlation of gene pairs in the non-p53-mutated breast cancer RNA-seq samples, while the upper right panel shows the correlation of gene pairs in the samples with (non-silent) p53 mutations. The diagonal is marked black as each gene’s self-correlations from both conditions are omitted. Genes are ordered by the median difference of z-score in correlation between that gene and all of the other genes present in both the rows and columns. This plot was made using the DGCA wrapper function to the gplots R package

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