Fig. 9

Summary of differential correlation results of PTEN in samples with and without PTEN mutations. a-b: Expression values for genes from breast cancer samples without PTEN mutation, or PTEN wildtype (WT; red, n = 816), compared to samples with non-silent PTEN mutations (blue, n = 27). For each gene pair, the expression of PTEN is on the x-axis, while the expression of FASLG a and IPCEF1 b are on the y-axis. For visualization purposes, a linear model was fit to the data in each comparison, with the grey lines representing 95% confidence intervals. c: For each gene, we plot both DGCA’s calculated differential correlation z-score between that gene and PTEN in PTEN non-mutated breast cancer samples and PTEN-mutated samples (x-axis), as well as limma’s differential expression t statistic for that gene’s differential expression between the same PTEN non-mutated samples and PTEN-mutated samples (y-axis). The correlation between the two measures is not significant (ρ = 0.13, p = 0.29). The blue line represents a linear model of the best fit, with the grey lines representing 95% confidence intervals