An improved method for functional similarity analysis of genes based on Gene Ontology

BMC Systems Biology

Table 2 The performances of different methods on seven experiments

GOA	Metric	simGIC	simUI	Resnik	Lin	JC	Teng	WIS
MF_IEA+	ECC	0.6219	0.6365	0.6027	0.6417	0.5612	0.6726	0.6439
	Pfam	0.638	0.6181	0.5718	0.5639	0.4908	0.5765	0.6205
	Seq	0.7172	0.5925	0.6686	0.6063	0.5459	0.5943	0.6802
	Res	0.9559	0.9671	0.9577	0.5705	0.2409	0.9762	0.9866
BP_IEA+	ECC	0.3981	0.4022	0.4444	0.4352	0.3707	0.4648	0.4127
	Pfam	0.4574	0.4505	0.4587	0.3727	0.3318	0.4679	0.4831
	Seq	0.7732	0.7304	0.7397	0.6369	0.5864	0.7293	0.7744
	Res	0.8373	0.8628	0.9004	0.9326	0.3345	0.9076	0.8533
CC_IEA+	ECC	0.3613	0.3757	0.3776	0.3683	0.2598	0.3741	0.3702
	Pfam	0.4974	0.5214	0.493	0.485	0.3123	0.496	0.5056
	Seq	0.75	0.6721	0.7113	0.6398	0.5013	0.6549	0.7561
	Res	0.9001	0.9337	0.9167	0.9359	0.3098	0.9371	0.8926
MF_ IEA-	ECC	0.5874	0.5782	0.4841	0.5161	0.5189	0.6502	0.5947
	Pfam	0.5824	0.5504	0.5221	0.5148	0.4503	0.5703	0.5865
	Seq	0.6665	0.5907	0.6512	0.5976	0.5219	0.6443	0.7032
	Res	0.9358	0.9304	0.9335	0.9376	0.3641	0.9605	0.9345
BP_IEA-	ECC	0.3887	0.3818	0.4257	0.4216	0.4113	0.4311	0.3945
	Pfam	0.4383	0.4253	0.4506	0.381	0.274	0.4171	0.4325
	Seq	0.7359	0.6949	0.7267	0.6269	0.5333	0.6754	0.7373
	Res	0.8697	0.8831	0.8929	0.9117	0.3573	0.8966	0.8561
CC_IEA-	ECC	0.3502	0.3527	0.3443	0.339	0.2519	0.3512	0.3492
	Pfam	0.4681	0.4872	0.4676	0.4562	0.3321	0.4725	0.4781
	Seq	0.7348	0.6499	0.7214	0.6441	0.5013	0.6875	0.7389
	Res	0.8691	0.9072	0.8921	0.9102	0.3441	0.911	0.8686

ISSN: 1752-0509