An improved method for functional similarity analysis of genes based on Gene Ontology

BMC Systems Biology

Table 4 AUC of the functional similarity measures for three GOs using BMA in the PPI task on human dataset (IEA+ and IEA-)

Methods	BP_IEA+	BP_IEA-	CC_IEA+	CC_IEA-	MF_IEA+	MF_IEA-
simUI	0.8747	0.8684	0.7803	0.7579	0.7125	0.6752
Teng	0.8916	0.8896	0.7856	0.7662	0.8089	0.7731
simGIC	0.9027	0.8959	0.8026	0.7796	0.7863	0.7531
Wang	0.9180	0.9088	0.8281	0.8231	0.8150	0.7670
Resnik	0.9404	0.9291	0.8537	0.8091	0.8682	0.8150
JC	0.8716	0.8828	0.7522	0.7968	0.7610	0.7601
Lin	0.9260	0.9172	0.8129	0.8151	0.8241	0.7772
ResnikGrasm	0.9249	0.9240	0.7991	0.7588	0.7963	0.8032
WangWV	0.8901	0.8905	0.8152	0.8189	0.8192	0.7673
simRel	0.9317	0.9306	0.8542	0.8291	0.8299	0.8178
WIS	0.9269	0.9300	0.8302	0.8110	0.8578	0.8463

ISSN: 1752-0509