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Table 5 Prediction on simulated missing GO annotations under BMA in CC sub-ontology

From: Interspecies gene function prediction using semantic similarity

m   MicroAvgF1 MacroAvgF1 1-RankLoss Fmax RAccuracy
1 H →H 96.03 ±0.09 86.84 ±0.19 96.49 ±0.02 95.36 ±0.09 17.12 ±1.89
  M+H →H 96.77 ±0.01 86.86 ±0.23 97.20 ±0.01 95.55 ±0.01 32.55 ±0.16
  M →M 95.48 ±0.04 86.19 ±0.22 93.83 ±0.01 94.98 ±0.04 12.22 ±0.73
  H+M →M 96.57 ±0.06 86.33 ±0.26 97.23 ±0.26 95.15 ±0.06 33.28 ±1.11
2 H →H 89.09 ±0.02 67.85 ±0.37 86.95 ±0.06 87.84 ±0.02 23.04 ±0.17
  M+H →H 90.82 ±0.02 68.47 ±0.37 90.54 ±0.05 88.84 ±0.02 35.24 ±0.13
  M →M 87.31 ±0.06 66.78 ±0.48 82.46 ±0.04 85.95 ±0.06 16.69 ±0.41
  H+M →M 90.53 ±0.01 67.23 ±0.52 91.43 ±0.03 88.16 ±0.01 37.84 ±0.10
3 H →H 82.54 ±0.06 53.68 ±0.25 79.52 ±0.02 81.76 ±0.06 25.08 ±0.27
  M+H →H 85.87 ±0.05 54.78 ±0.27 86.17 ±0.09 83.74 ±0.05 39.38 ±0.20
  M →M 81.45 ±0.05 52.84 ±0.55 76.54 ±0.07 77.69 ±0.05 24.71 ±0.19
  H+M →M 84.02 ±0.10 53.83 ±0.56 82.41 ±0.12 79.60 ±0.10 35.13 ±0.41
  1. q is the number of simulated missing annotations of a gene. H →H directly uses GO annotations of Human to predict annotations of Human genes. M+H →H uses GO annotations of genes from Mouse and Human to predict annotations of Human genes. M →M and H+M →M follow the similar protocol, but make prediction for Mouse genes. The data in boldface is the statistically significant best among these comparing methods for a particular target species, and the significance is checked by paired t-test at 95% confidence intervals