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Fig. 3 | BMC Systems Biology

Fig. 3

From: Sig2GRN: a software tool linking signaling pathway with gene regulatory network for dynamic simulation

Fig. 3

Simulated gene expression of Bax in a and b and Bcl-2 in d and e under DNA damage stimuli. ATR and DNA-PK are selected as input nodes. The parameter settings are only for illustration purpose. Both the simulated gene expression patterns of the Boolean model (plots a and d) and the thermodynamic model (plots b and e) agree with the time-series wet-lab experimental data of c Bax and f Bcl-2 [35]. The experimental data consist of the ratios of gene expression levels between UV light treated group and control group

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BMC Systems Biology

ISSN: 1752-0509

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