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Fig. 3 | BMC Systems Biology

Fig. 3

From: SParSE++: improved event-based stochastic parameter search

Fig. 3

Interpolation comparison between SParSE and SParSE++ for the reversible isomerization model with \(\mathcal {P}_{\mathcal {E}} = 0.60, \ \epsilon _{\mathcal {P}_{\mathcal {E}}} = 0.01\), and k 0=[0.2559 0.3858]. Sub-figures a-c display three successive interpolation attempts made by SParSE, where the solution hypersurface is reached by the ninth candidate biasing parameter set. Sub-figure d represents interpolation by SParSE++, whose first output successfully finds k . Blue and green circles denote counters (\(\hat {p} \cdot N_{S}\)) from past biasing parameters for R 1 and R 2, respectively. Blue and green dashed lines represent interpolants corresponding to past counters. Yellow horizontal line is the target counter (\(\mathcal {P}_{\mathcal {E}} \cdot N_{S}\)). Red triangles represent counters corresponding to candidate biasing parameters

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