Skip to main content

Table 1 Number of experimentally confirmed miRNA-mRNA associations by the ground-truth data

From: DMirNet: Inferring direct microRNA-mRNA association networks

 

Single Method

Ensemble Method

Corpcor

Space

MIND

C&S

C&M

S&M

C&S&M

EMT

Whole

35

45

24

45

34

35

41

Bootstrap

32

38

25

40

24

37

40

MCC

Whole

200

183

210

204

206

201

209

Bootstrap

211

204

207

201

217

220

216

BR

Whole

98

83

95

90

94

97

102

Bootstrap

107

95

99

99

102

100

105

  1. The Top 100 correlations for each miRNA were selected from each experiment for performance comparison. To evaluate the effect of three direct correlation inference methods, bootstrapping and Ensemble approach, we performed a comparative study using EMT, MCC and BR datasets. Corpcor (denoted as C) is the partial correlation estimation method, SPACE (denoted as S) is the sparse partial correlation estimation method, and MIND (denoted as M) is the mutual information-based network deconvolution method. ‘Whole’ means that the whole expression profiles were used to infer a direct correlation matrix, and ‘Bootstrap’ means that 100 direct correlation matrices were computed using 100 bootstrapped samples and then aggregated based on an inverse-rank-product method