Skip to main content
Fig. 5 | BMC Systems Biology

Fig. 5

From: Understanding key features of bacterial restriction-modification systems through quantitative modeling

Fig. 5

Decreasing AhdI dissociation constant of dimerization. K 1 is decreased from the high value corresponding to mostly monomers in the solution, to the low value corresponding to mostly dimers in the solution, and the effect is assessed on a The dynamics of the protein synthesis. The black line corresponds to all monomers in the solution (wt), while the light gray line corresponds to all dimers in the solution. The curves in-between (in different shades of gray) correspond to the gradually decreasing values of K 1. The relative protein amounts for a wt system (on the vertical axis) are derived from in-vitro transcription activity measurements in [6]. x indicated in the legend corresponds to the relative decrease of K 1 (e.g. x = 4 is a four-fold decrease). b The first dynamical property observable, corresponding to the relative delay of R with respect to M expression. The delay is normalized with respect to the wild type (corresponding to one). c The second dynamical property observable, corresponding to the transition velocity from “OFF” to “ON” state, represented by the maximal slope of the R expression curve. d The third dynamical property observable, corresponding to the stability of R steady-state levels (see Methods)

Back to article page