Fig. 8From: Understanding key features of bacterial restriction-modification systems through quantitative modelingIncreasing the dissociation constant of dimerization of wt EcoRV system. The rescaled dissociation constant of dimerization \( {\overline{K}}_1 \) is increased from the lower value with dimers in the solution corresponding to wt system, to the high value, where mostly monomers are in the solution. The effect of the increasing dissociation constant of dimerization is assessed on: a The dynamics of R and M synthesis. The solid and the dashed line correspond to R and M dynamics, respectively. Different shades of gray correspond to the increasing value of the dissociation constant of dimerization, with the black line and the light gray line corresponding to the wild type and the monomer case, respectively. b The transition velocity vmax from “OFF” to “ON” state. c The stability of R steady-state levelsBack to article page