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Table 3 Unannotated metabolic reactions in the T. erythraeum genome but included in the model based on homology to related organisms and/or to close gaps for biomass formation

From: The use of genome-scale metabolic network reconstruction to predict fluxes and equilibrium composition of N-fixing versus C-fixing cells in a diazotrophic cyanobacterium, Trichodesmium erythraeum

Pathway Proposed function E.C. Number Gene Annotated function Closest organism
Newly/Improved Annotated
 Amino Acid Metabolism L-alanine: glyoxylate aminotransferase Tery_3167 Serine: glyoxylate transaminase Leptolyngbya sp. NIES 3755
L-serine: pyruvate aminotransferase,, Tery_3167 Serine: glyoxylate transaminase Leptolyngbya sp. NIES 3755
L-aspartase Tery_1328 Fumarase Nitrosococcus oceani
L-arogenate: 2-oxoglutarate aminotransferase Tery_0293 L-aspartate aminotransferase Pleurocapsa sp. PCC 7327
L-threonine ammonium-lyase Tery_4742 Pyridoxal-5’-phosphate-dependent enzyme, beta subunit/cysteine synthase A Zymomonas mobilis subsp. NRRL B-12526
 Isoprenoid Synthesis Tocopherol phytyltransferase Tery_3881 Homogentisate phytyltransferase Nostoc sp. NIES-3756
 Pigment Metabolism Chlorophyllide-a: NADP+ oxidoreductase 18445Tery_3563 NmrA-like Amborella trichopoda
 Secondary Carbon Metabolism Citramalate synthase Tery_2253 2-Isopropylmalate synthase Dehalococcoides mccartyi VS
 Sulfur Metabolism O-succinylhomoserine thiol lyase Tery_0352 8-Amino-7-oxononanoate synthase Nostoc sp. PCC 7524
 Tricarboxylic Acid Cycle Isocitrate lyase Tery_4268 2,3-Dimethylmalate lyase/methylisocitrate lyase Candidatus Nitrososphaera gargensis
Assumed Promiscuous
 Amino Acid Metabolism 4-Hydroxyglutamate transaminase Tery_0293 L-aspartate aminotransferase T. erythraeum
 Cofactor and Energy Carrier Metabolism Dihydroneopterin P i dephosphorylase Tery_1519 Inorganic diphosphatase
Dihydroneopterin PPP i dephosphorylase Tery_1519 Inorganic diphosphatase
 Lipid Metabolism/Secondary Carbon Metabolism Glycoaldehyde dehydrogenase Tery_2599 Aldehyde dehydrogenase
 Nucleotide Metabolism 3’-5’-Nucleotide phosphodiesterase: cAMP Many 3’-5’-Nucleotide phosphodiesterase: NMP
Missing (but Essential) Gene
 Cofactor and Energy Carrier Metabolism (R)-Pantoate:NADP+2-oxidoreductase None None None